Issue 8, 2025
From the journal:

New Journal of Chemistry

A reduction-responsive self-reporting fluorescent prodrug for real-time monitoring of 5-ASA release†

Yuan Wang,‡abc   Yingjie Chen,‡d   Wenchao Wang,e   Ruhui Yang,f   Yuhan Gao,ac   Yanlong Liu*g  and  Sicheng Tang ORCID logo *ac  

* Corresponding authors

a Postgraduate Training Base Alliance of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China

b School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310052, China

c Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang 325000, China
E-mail: sichengtang@ucas.ac.cn

d Cixi Biomedical Research Institute, Wenzhou Medical University, Wenzhou, Zhejiang 325000, China

e School of Pharmacy, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China

f Suzhou Kowloon Hospital, Shanghai Jiao Tong University School of Medicine, Suzhou, Jiangsu 215028, China

g School of Mental Health, Wenzhou Medical University, Wenzhou, Zhejiang 325000, China
E-mail: china.benjaminlyl@wmu.edu.cn

Abstract

A fluorescent prodrug (NPD) was developed by conjugating 5-aminosalicylic acid with a naphthalimide fluorophore via a reduction-sensitive azo linkage. NPD exhibits quenched fluorescence but generates strong fluorescence upon reduction-triggered drug release. This system enables real-time monitoring of drug activation while maintaining therapeutic efficacy, as demonstrated by ROS-scavenging and anti-inflammatory activities.

Graphical abstract: A reduction-responsive self-reporting fluorescent prodrug for real-time monitoring of 5-ASA release

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Article information

DOI
https://doi.org/10.1039/D4NJ04860A
Article type
Communication
Submitted
11 Nov 2024
Accepted
28 Jan 2025
First published
29 Jan 2025

New J. Chem., 2025,49, 3010-3014

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A reduction-responsive self-reporting fluorescent prodrug for real-time monitoring of 5-ASA release

Y. Wang, Y. Chen, W. Wang, R. Yang, Y. Gao, Y. Liu and S. Tang, New J. Chem., 2025, 49, 3010 DOI: 10.1039/D4NJ04860A

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