Light-triggered quenching of the 19F-MRI signal from micelle-encapsulated PERFECTA

Claire Leterrier; Guillaume Pinna; Marie Vandamme; Mélissa Glatigny; Erwan Selingue; Françoise Geffroy; Sébastien Mériaux; Edmond Gravel; Eric Doris

doi:10.1039/D5NH00468C

Light-triggered quenching of the ¹⁹F-MRI signal from micelle-encapsulated PERFECTA

Claire Leterrier,

^a Guillaume Pinna,

^bc Marie Vandamme,

^bc Mélissa Glatigny,

^d Erwan Selingue,

^d Françoise Geffroy,

^d Sébastien Mériaux,

*^d Edmond Gravel

*^a and Eric Doris

*^a

Author affiliations

* Corresponding authors

^a CEA, INRAE, Département Médicaments et Technologies pour la Santé (DMTS), SCBM, Université Paris-Saclay, 91191 Gif-sur-Yvette, France
E-mail: edmond.gravel@cea.fr, eric.doris@cea.fr

^b CEA, Stabilité Génétique Cellules Souches et Radiations, Université Paris Cité, Plateforme PARi, 92260 Fontenay-aux-Roses, France

^c CEA, Stabilité Génétique Cellules Souches et Radiations, Université Paris-Saclay, Plateforme PARi, 92260 Fontenay-aux-Roses, France

^d CEA, CNRS, BAOBAB, NeuroSpin, Université Paris-Saclay, 91191 Gif-sur-Yvette, France
E-mail: sebastien.meriaux@cea.fr

Abstract

We report the development of a fluorinated micellar nanosystem whose ¹⁹F-MRI signal can be selectively dimmed by application of an external stimulus. A photo-activatable quencher unit (ferrocene) was co-encapsulated with the superfluorinated PERFECTA probe in colloidal micelles. While pristine micelles were MRI responsive (“On” state), their irradiation by light triggered the “Off” MRI-state of PERFECTA.

Supplementary files

Article information

DOI: https://doi.org/10.1039/D5NH00468C
Article type: Communication
Submitted: 08 Jul 2025
Accepted: 10 Sep 2025
First published: 19 Sep 2025
This article is Open Access

Download Citation

Nanoscale Horiz., 2025,10, 3369-3375

Permissions

Request permissions

Light-triggered quenching of the ¹⁹F-MRI signal from micelle-encapsulated PERFECTA

C. Leterrier, G. Pinna, M. Vandamme, M. Glatigny, E. Selingue, F. Geffroy, S. Mériaux, E. Gravel and E. Doris, Nanoscale Horiz., 2025, 10, 3369 DOI: 10.1039/D5NH00468C

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

Nanoscale Horizons

Light-triggered quenching of the ¹⁹F-MRI signal from micelle-encapsulated PERFECTA

Abstract

Supplementary files

Article information

Download Citation

Permissions

Light-triggered quenching of the ¹⁹F-MRI signal from micelle-encapsulated PERFECTA

Social activity

Search articles by author

Spotlight

Advertisements