Engineering versatile supramolecular structures with tetravalent DNA-traptavidin building blocks

Abstract

Proteins offer great promise for nanoscale biomaterials, but precise assembly is challenging. This study presents DNA-protein hybrid building blocks (DTHBs) using traptavidin and biotinylated DNA for controlled assembly to linear chains, spherical clusters, and ordered lattices, enabling sophisticated, programmable architectures with potential biomedical applications, including drug delivery and biosensors.