A review on the green synthesis of metal (Ag, Cu, and Au) and metal oxide (ZnO, MgO, Co3O4, and TiO2) nanoparticles using plant extracts for developing antimicrobial properties

Abstract

Green synthesis (GS) is a vital method for producing metal nanoparticles with antimicrobial properties. Unlike traditional methods, green synthesis utilizes natural substances, such as plant extracts, microorganisms, etc., to create nanoparticles. This eco-friendly approach results in non-toxic and biocompatible nanoparticles with superior antimicrobial activity. This paper reviews the prospects of green synthesis of metal nanoparticles of silver (Ag), copper (Cu), gold (Au) and metal oxide nanoparticles of zinc (ZnO), magnesium (MgO), cobalt (Co₃O₄), and titanium (TiO₂) using plant extracts from tissues of leaves, barks, roots, etc., antibacterial mechanisms of metal and metal oxide nanoparticles, and obstacles and factors that need to be considered to overcome the limitations of the green synthesis process. The clean surfaces and minimal chemical residues of these nanoparticles contribute to their effectiveness. Certain metals exhibit enhanced antibacterial properties only in GS methods due to the presence of bioactive compounds from natural reducing agents such as Au and MgO. GS improves TiO₂ antibacterial properties under visible light, while it would be impossible without UV activation. These nanoparticles have important antimicrobial properties for treating microbial infections and combating antibiotic resistance against bacteria, fungi, and viruses by disrupting microbial membranes, generating ROS, and interfering with DNA and protein synthesis. Nanoscale size and large surface area make them critical for developing advanced antimicrobial treatments. They are effective antibacterial agents for treating infections, suitable in water purification systems, and fostering innovation by creating green, economically viable antibacterial materials. Therefore, green synthesis of metal and metal oxide nanoparticles for antibacterial agents supports several United Nations Sustainable Development Goals (SDGs), including health improvement, sustainability, and innovation.