From the journal:

RSC Mechanochemistry

Benzyne formations and reactions with amines under solvent-free conditions in a mixer mill

Ganesh Vijay Raskar,ab   Dipankar Royab  and  Carsten Bolm ORCID logo *b  

* Corresponding authors

a PI Industries Ltd, Udaisagar Road, Udaipur, 313001 Rajasthan, India

b Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, D-52074 Aachen, Germany
E-mail: carsten.bolm@oc.rwth-aachen.de
Fax: +49 241 80 92 391
Tel: +49 24 80 94 675

Abstract

Under solventfree mechanochemical conditions, treatment of Kobayashi's o-trimethylsilylphenyl triflate with tetrabutyl-ammonium fluoride hydrate (TBAF·H2O) generates benzyne, which reacts with amines to give N-phenylated products.

Graphical abstract: Benzyne formations and reactions with amines under solvent-free conditions in a mixer mill

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Article information

DOI
https://doi.org/10.1039/D5MR00109A
Article type
Communication
Submitted
27 Aug 2025
Accepted
06 Oct 2025
First published
08 Oct 2025
This article is Open Access
Creative Commons BY license

RSC Mechanochem., 2025, Advance Article

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Benzyne formations and reactions with amines under solvent-free conditions in a mixer mill

G. V. Raskar, D. Roy and C. Bolm, RSC Mechanochem., 2025, Advance Article , DOI: 10.1039/D5MR00109A

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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