Synthesis of cyclic carbonates via silver-catalysed fixation of CO2 to propargyl alcohols under mechanochemical conditions

Abstract

This paper describes the development of a mechanochemical method for the synthesis of cyclic carbonate esters via CO₂ fixation on propargyl alcohols. This solvent-free process is rapid and occurs under ambient conditions, thus offering a sustainable and efficient alternative to conventional solvent-based protocols. The mechanochemistry, which utilises the energy generated from milling, has the advantage of minimising waste, reducing reaction times, and simplifying work-up. The developed protocol demonstrates broad functional group tolerance, high yields, and the elimination of complex setups, thus highlighting its potential for application in organic and pharmaceutical synthesis.