Enhanced anti-inflammatory and anti-fibrotic effects of nanoparticles loaded with a combination of Aloe veraMoringa oleifera extracts

Abstract

Metabolic associated steatohepatitis characterized by lipid accumulation, inflammation and fibrosis, is a growing global health issue, contributing to severe liver-related mortality. With limited effective treatments available, there is an urgent need for novel therapeutic strategies. Moringa oleifera, rich in antioxidants, offers potential for combating steatohepatitis, but its cytotoxicity presents challenges. Aloe vera, renowned for its cytocompatibility and anti-inflammatory effects, shows promise in mitigating these risks. Using infrared spectrometry and mass spectrometry, we identified 1586 metabolites from both plants across 84 chemical classes. By encapsulating these phytochemicals in nanoparticles, we achieved increased solubility, cytocompatibility, and gene modulation to hepatic stellate cells affected by steatohepatitis. Chemoinformatic analysis revealed bioactive metabolites, including hesperetin analogs, known to inhibit TGF-β. Our results demonstrate that these nanoparticles not only improved gene expression modulation related to metabolic associated steatohepatitis, particularly TGF-β and COL1A1, but also outperformed free compounds, highlighting their potential as a novel therapeutic approach.

Graphical abstract: Enhanced anti-inflammatory and anti-fibrotic effects of nanoparticles loaded with a combination of Aloe vera–Moringa oleifera extracts

Supplementary files

Article information

Article type
Research Article
Submitted
29 Sep 2024
Accepted
25 Dec 2024
First published
26 Dec 2024

Mol. Omics, 2025, Advance Article

Enhanced anti-inflammatory and anti-fibrotic effects of nanoparticles loaded with a combination of Aloe veraMoringa oleifera extracts

G. I. Carballo-López, J. Ojeda-González, K. D. Martínez-García, K. E. Cervantes-Luevano, A. Moreno-Ulloa and A. B. Castro-Ceseña, Mol. Omics, 2025, Advance Article , DOI: 10.1039/D4MO00195H

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