Traceable nanoparticles with mitochondria-targeting pyruvate-Cu induce cuproptosis for enhanced triple-negative breast cancer therapy in a mouse model

Chen Peng; Jiaxin Li; Nan Wang; Xinyue Zhang; Wen Zhang; Zhirui Li; Keyi Zhang; Yangchaowei Ji; Wei He; Yan Li

doi:10.1039/D5MH01047K

Traceable nanoparticles with mitochondria-targeting pyruvate-Cu induce cuproptosis for enhanced triple-negative breast cancer therapy in a mouse model

Chen Peng,^a Jiaxin Li,^a Nan Wang,^a Xinyue Zhang,^a Wen Zhang,^a Zhirui Li,^a Keyi Zhang,^a Yangchaowei Ji,^a Wei He^b and Yan Li

*^a

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* Corresponding authors

^a Beijing Key Laboratory for Bioengineering and Sensing Technology, School of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing, P. R. China
E-mail: liyan310@ustb.edu.cn

^b School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing, P. R. China

Abstract

We develop pyruvate with good biocompatibility and mitochondria-targeting ability as a copper ionophore (pyruvate-Cu). To further address its drawbacks, traceable nanoparticles are constructed to deliver pyruvate-Cu for triple negative breast cancer (TNBC) treatment. In vitro and in vivo results demonstrate that this work provides an efficient platform for enhanced TNBC therapy.

Materials Horizons

Traceable nanoparticles with mitochondria-targeting pyruvate-Cu induce cuproptosis for enhanced triple-negative breast cancer therapy in a mouse model

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Traceable nanoparticles with mitochondria-targeting pyruvate-Cu induce cuproptosis for enhanced triple-negative breast cancer therapy in a mouse model

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