Sequence-Controlled Peptoid Hydrogels for Neuronal Trans-Differentiation: A Synthetic Biomaterials Approach in Future Neuroregenerative Research

Abstract

Peptide-based hydrogels stimulate stem cell differentiation into neurons, improve neuroprotection, and aid in spinal cord/brain injury repair by moderating inflammatory responses and activating endogenous healing pathways. Peptoid-based hydrogels, with superior enzymatic stability and tunable properties, offer a promising alternative but remain unexplored in neurodegenerative therapies. Thus, future study should focus on optimizing peptoid-based hydrogel formulations, which could considerably progress neuroregenerative therapies in neuroscience research.