Zinc-based metal organic framework loaded-electrospun PVA/PEO/l-arginine nanofibers as efficient antimicrobial scaffolds for burn skin wound healing

Abstract

Burns represent a significant health challenge, causing extensive skin damage and necessitating advanced wound care strategies. This study explores the development of electrospun NFs composed of polyvinyl alcohol (PVA)/polyethylene oxide (PEO)/L-arginine (L-Arg) with a ratio of ca. (4 : 1 : 0.5), with/without loading zinc-based metal–organic frameworks (Zn-MOF). The synthesized Zn-MOF and the composite nanofiber were fully examined by FT-IR, XRD, SEM, and EDX analyses. Meanwhile, the incorporation effect of PEO into the PVA NFs enhanced the mechanical strength of the nanofibers, while the incorporation of Zn-MOFs enhanced the antimicrobial activity of the nanofibers. Antimicrobial testing demonstrated significant broad-spectrum efficacy vs. Gram-positive bacteria (Bacillus subtilis, Staphylococcus aureus), Gram-negative bacteria (Escherichia coli, Klebsiella pneumoniae), and yeast, e.g. Candida albicans, with the highest inhibition zones observed particularly with loading 10% Zn-MOF into the formulations. In vivo evaluation using a rat burn model revealed significantly accelerated wound healing, enhanced epidermal regeneration, increased wound contraction percentage, and elevated vascular endothelial growth factor (VEGF) expression in the Zn-MOF-treated groups. Histopathological analysis confirmed superior tissue regeneration and reduced inflammation, particularly for nanofibers containing high Zn-MOF concentrations. These findings indicate that Zn-MOF-loaded PVA/PEO/L-Arg nanofibers are promising candidates for the effective treatment of burn wounds, offering both antimicrobial protection and improved tissue healing.

Graphical abstract: Zinc-based metal organic framework loaded-electrospun PVA/PEO/l-arginine nanofibers as efficient antimicrobial scaffolds for burn skin wound healing

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Article information

Article type
Paper
Submitted
30 Apr 2025
Accepted
22 Aug 2025
First published
26 Aug 2025
This article is Open Access
Creative Commons BY license

Mater. Adv., 2025, Advance Article

Zinc-based metal organic framework loaded-electrospun PVA/PEO/L-arginine nanofibers as efficient antimicrobial scaffolds for burn skin wound healing

E. Kenawy, Z. S. Ghaly, E. A. Kamoun, W. E. Yousuf, A. M. Shokr, Y. S. Salib and E. E. Elmohamady, Mater. Adv., 2025, Advance Article , DOI: 10.1039/D5MA00420A

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