A microfluidic platform for studying supercritical fluid crystallization and its applications

Abstract

We demonstrate here the development and use of an on-chip crystallization microfluidic device combined with in situ analytical techniques for supercritical antisolvent crystallization. The setup facilitated real-time observation of crystallization events under pressure, giving critical insights into the time-dependent dynamics of the crystallization process. By integrating Raman spectroscopy for continuous monitoring, the system enabled precise control of local species concentrations during diffusion-driven crystallization. The microfluidic platform demonstrated effectiveness in rapid crystal screening and the identification of new co-crystals.