Issue 28, 2025

A catechol-catalyzed photocatalytic carbonylative four-component reaction of alkylboronic acids with aldehydes and amines

Abstract

Carbonylation reactions employing CO as an easily accessible Cl source have emerged as one of the most powerful tools for constructing carbonyl-containing compounds from readily available starting materials. Despite the impressive achievements on carbonylative transformations, a fundamental limitation of these approaches lies in their reliance on transition metal catalysis or a stoichiometric amount of activating reagents. Herein, we report the first photo-induced catechol-catalyzed four-component carbonylation reaction of alkylboronic acids with aldehydes and amines. A range of valuable substituted α-amino ketones was produced in moderate to good yields.

Graphical abstract: A catechol-catalyzed photocatalytic carbonylative four-component reaction of alkylboronic acids with aldehydes and amines

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Article information

Article type
Communication
Submitted
14 May 2025
Accepted
16 Jun 2025
First published
30 Jun 2025
This article is Open Access
Creative Commons BY license

Green Chem., 2025,27, 8492-8497

A catechol-catalyzed photocatalytic carbonylative four-component reaction of alkylboronic acids with aldehydes and amines

Q. Li, L. Wang and X. Wu, Green Chem., 2025, 27, 8492 DOI: 10.1039/D5GC02383A

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