Issue 28, 2025

Photocatalytic 1,2-thiosulfonylation of alkenes with thiophenols and sulfonyl chlorides promoted by directly knitted copper polymers

Abstract

Considering the importance of organosulfur compounds in synthetic and biological chemistry, copper-containing hypercrosslinked polymers (HCPs-Cu 1a–d) with uniformly dispersed Cu centers were prepared by using the “direct knitting” strategy without any premodification, which exhibited outstanding catalytic activity towards visible light-promoted three-component 1,2-thiosulfonylation of alkenes with thiophenols and sulfonyl chlorides. Besides the remarkably broad substrate scopes featuring diverse electronic properties, functional groups and heterocycles (56 examples), and good activity (up to 96%), solid HCP-Cu 1a could be reused up to 8 times without loss of catalytic activity. Notably, the ease of scaling up to gram-scale and late-stage functionalizations of a myriad of alkene-containing natural products and drug molecules (15 examples) highlighted the great synthetic utility of HCP-Cu 1a as a competitive photocatalyst.

Graphical abstract: Photocatalytic 1,2-thiosulfonylation of alkenes with thiophenols and sulfonyl chlorides promoted by directly knitted copper polymers

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Article information

Article type
Paper
Submitted
28 Apr 2025
Accepted
20 Jun 2025
First published
21 Jun 2025

Green Chem., 2025,27, 8585-8593

Photocatalytic 1,2-thiosulfonylation of alkenes with thiophenols and sulfonyl chlorides promoted by directly knitted copper polymers

L. Chen, K. Zhang, Y. Shen, Z. Chen and W. Fang, Green Chem., 2025, 27, 8585 DOI: 10.1039/D5GC02121A

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