The Low-Temperature Selective Oxidation of Alcohols and a One-Pot Oxidative Esterification Using an IBS(III/V)/Oxone Catalysis

Abstract

The IBS/oxone catalyst system has been improved for selective alcohol oxidation at near-room temperature (30 °C), overcoming the limitations of the conventional high-temperature (70 °C) method. An NMR spectroscopy analysis identified the rate-determining step, leading to the development of optimized conditions based on the pre-generation of IBS(III) and a phase-transfer catalyst. These improvements enhanced the functional-group tolerance and substrate scope, including thermally unstable, acid-sensitive, or overoxidation-prone alcohols. Furthermore, the system was successfully applied to one-pot oxidative esterification reactions, demonstrating its versatility and synthetic utility in mild oxidation processes.

Supplementary files

Article information

Article type
Communication
Submitted
09 Apr 2025
Accepted
07 Jul 2025
First published
07 Jul 2025
This article is Open Access
Creative Commons BY-NC license

Green Chem., 2025, Accepted Manuscript

The Low-Temperature Selective Oxidation of Alcohols and a One-Pot Oxidative Esterification Using an IBS(III/V)/Oxone Catalysis

R. Kondo, M. Uyanik and K. Ishihara, Green Chem., 2025, Accepted Manuscript , DOI: 10.1039/D5GC01737H

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