From the journal:

Green Chemistry

Continuous-flow electrochemical benzylic dehydrogenation of arylalkanes to arylalkenes†

Xuan-Xuan Du,a   Shu-Fan He,a   Daixi Li,*bc   Yong Jiang,ad   Chen Zhud  and  Tao Shen ORCID logo *a  

* Corresponding authors

a Frontiers Science Center for Transformative Molecules (FSCTM), Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Chemistry and Chemical Engineering, Zhangjiang Institute for Advanced Study, Shanghai Jiao Tong University, Shanghai, P. R. China
E-mail: taoshen@sjtu.edu.cn

b Department of Respiratory and Critical Care Medicine, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China

c The School of Clinical Medicine, Fujian Medical University, Fuzhou, China
E-mail: lidaixi@xmu.edu.cn

d Eastern Institute for Advanced Study, Eastern Institute of Technology, Ningbo, China

Abstract

A novel acid-mediated continuous-flow electrochemical strategy for arylalkane dehydrogenation was described. This oxidant- and hydrogen acceptor-free protocol proceeds in a single step under mild conditions, affording a broad range of arylalkenes as single regioisomers in a short reaction time, providing a direct, scalable, and practical method for the synthesis of arylalkenes.

Graphical abstract: Continuous-flow electrochemical benzylic dehydrogenation of arylalkanes to arylalkenes

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Article information

DOI
https://doi.org/10.1039/D5GC01442E
Article type
Communication
Submitted
24 Mar 2025
Accepted
07 Jun 2025
First published
09 Jun 2025

Green Chem., 2025, Advance Article

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Continuous-flow electrochemical benzylic dehydrogenation of arylalkanes to arylalkenes

X. Du, S. He, D. Li, Y. Jiang, C. Zhu and T. Shen, Green Chem., 2025, Advance Article , DOI: 10.1039/D5GC01442E

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