Extended recommendations on the nomenclature for microbial catabolites of dietary (poly)phenols, with a focus on isomers

Claudio Curti; Michael N. Clifford; Colin D. Kay; Pedro Mena; Ana Rodriguez-Mateos; Daniele Del Rio; Gordon J. McDougall; Gary Williamson; Cristina Andres-Lacueva; Letizia Bresciani; Britt Burton Freeman; Aedin Cassidy; Yves Desjardin; Cesar G. Fraga; Chris. C. I. Gill; Paul A. Kroon; Nikolai Kuhnert; Iziar A. Ludwig; Claudine Manach; Dragan Milenkovic; Cláudia Nunes dos Santos; Patricia I. Oteiza; Gema Pereira-Caro; Francisco A. Tomás Barberán; David S. Wishart; Alan Crozier

doi:10.1039/D4FO06152G

Extended recommendations on the nomenclature for microbial catabolites of dietary (poly)phenols, with a focus on isomers†

Claudio Curti,

^a Michael N. Clifford,

^bc Colin D. Kay,^d Pedro Mena,

^ef Ana Rodriguez-Mateos,

^g Daniele Del Rio,

^ef Gordon J. McDougall,

^h Gary Williamson,^c Cristina Andres-Lacueva,^ij Letizia Bresciani,

^e Britt Burton Freeman,

^k Aedin Cassidy,^l Yves Desjardin,

^m Cesar G. Fraga,

ⁿ Chris. C. I. Gill,^o Paul A. Kroon,

^p Nikolai Kuhnert,

^q Iziar A. Ludwig,

^r Claudine Manach,^s Dragan Milenkovic,

^t Cláudia Nunes dos Santos,^u Patricia I. Oteiza,

ⁿ Gema Pereira-Caro,

^v Francisco A. Tomás Barberán,

^w David S. Wishart^x and Alan Crozier

*^yz

Author affiliations

* Corresponding authors

^a BioOrganic Synthesis Unit, Department of Food and Drug, University of Parma, Parma, Italy

^b School of Bioscience and Medicine, University of Surrey, Guildford, UK

^c Department of Nutrition, Dietetics and Food, Monash University, Notting Hill, Victoria, Australia

^d Department of Pediatrics, University of Arkansas Medical School, Little Rock, AR, USA

^e Human Nutrition Unit, Department of Food and Drug, University of Parma, Parma, Italy

^f Microbiome Research Hub, University of Parma, Parma, Italy

^g Department of Nutritional Sciences, Kings College, London, UK

^h The James Hutton Research Institute, Invergowrie, Dundee, UK

ⁱ Department of Nutrition, Food Science and Gastronomy, University of Barcelona, Barcelona, Spain

^j CIBER Frailty and Healthy Aging (CIBERfes), Institute of Health Carlos III, Barcelona, Spain

^k Department of Food Science and Nutrition, Illinois Institute of Technology, Chicago, ILL, USA

^l Institute for Food Security, Queen's University, Belfast, Northern Ireland, UK

^m Institute for Nutrition and Functional Food, Laval University, Québec, Canada

ⁿ Department of Nutrition, University of California, Davis, CA, USA

^o Nutrition Innovation Centre for Food and Health, Ulster University, Coleraine, UK

^p Quadram Institute, Norwich, UK

^q School of Science, Constructor University, Bremen, Germany

^r Center for Nutrition Research, University of Navarra, Pamplona, Spain

^s Université Clermont Auvergne, INRAE, Human Nutrition Unit, Clermont-Ferrand, France

^t Plants for Human Health Institute, Food Bioprocessing and Nutrition Sciences Department, North Carolina State University, Kannapolis, NC, USA

^u NOVA Medical School, NOVA University of Lisbon, Lisbon, Portugal

^v Department of Food Science and Health, Andalusian Institute of Agricultural and Fisheries Research and Training, Córdoba, Spain

^w Quality, Safety and Bioactivity of Plant-Derived Foods CEBAS-CSIC, Espinardo University Campus, Murcia, Spain

^x Department of Biological Sciences, University of Alberta, Edmonton, Canada

^y Department of Chemistry, King Saud University, Riyadh, Saudi Arabia
E-mail: alan.crozier44@gmail.com

^z School of Medicine, Dentistry and Nursing, University of Glasgow, Glasgow, UK

Abstract

There is an increasing body of evidence indicating that phenolic compounds derived from microbiota-mediated breakdown of dietary (poly)phenolics in the colon are at least partially responsible for the beneficial effects of a plant-based diet. Investigating the role of these catabolites and defining their particular biological effects is challenging due to the complex microbial pathways and the diversity of structures that are produced. When reviewing the data this is further exacerbated by the inconsistency and lack of standardization in naming the microbial phenolics. Here we update the nomenclature of colonic catabolites of dietary (poly)phenols, extending the proposals of Kay et al. (Am. J. Clin. Nutr., 2020, 112, 1051–1068, DOI: 10.1093/ajcn/nqaa204), by providing additional structures, and addressing the difficulties that can arise when investigating regioisomers and stereoisomers, where subtle differences in structure can have a substantial impact on bioactivity. The information provided will help to better harmonize the literature, facilitate data retrieval and provide a reference for researchers in several fields, especially nutrition and biochemistry.

Food & Function

Extended recommendations on the nomenclature for microbial catabolites of dietary (poly)phenols, with a focus on isomers†

Abstract

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Extended recommendations on the nomenclature for microbial catabolites of dietary (poly)phenols, with a focus on isomers

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