Induction of helical chirality in tetrahedral transition metal complexes with non-bridging monodentate oxazolines

Abstract

Chirality on C4-atoms of non-bridging monodentate oxazolines direct stereoselective formation of helical chirality in [M(1)₂X₂] tetrahedral metal complexes of zinc(II), cadmium(II) and cobalt(II) halides, as revealed by their crystal structures. This feature was used to prepare a set of helically chiral derivatives with various structural motifs. In particular, bulkiness, non-covalent interactions and choice of point chirality combinations were found to strongly affect induction of chirality on the metal atom. The substituent influence on complexation and chiral induction was analyzed using XRD-diffraction studies, NMR, UV-Vis and CD spectroscopies, as well as DFT calculations.