SCHEDULED MAINTENANCE:
Anti-breast cancer stem cell activity of titanocene complexes of non-steroidal anti-inflammatory drugs
Olympia
Mouriki, 
†a
Ginevra
Passeri,
†a
Sarah D.
Lamorte,
a
Kogularamanan
Suntharalingam
*a
and
Alexander F. R.
Kilpatrick
*a
†a
Ginevra
Passeri,
†a
Sarah D.
Lamorte,
a
Kogularamanan
Suntharalingam
*a
and
Alexander F. R.
Kilpatrick
*a
Abstract
Titanocene(IV)-NSAID complexes Cp2Ti(mefenamate)2 (4) and Cp2Ti(flufenamate)2 (5) show enhanced redox stability and potent cytotoxicity against breast cancer stem cells (CSCs), with 5 rivaling salinomycin and cisplatin. Complex 5 induces DNA damage and apoptosis, and its nanoparticle encapsulation improves biocompatibility. This is the first report targeting breast CSCs with titanocene-based metallodrugs.
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