Issue 28, 2025

A subcellularly targeted photocaged inhibitor for mitochondrial carbonic anhydrase V

Abstract

We report the first photoactivatable inhibitor specifically targeting mitochondrial CA-V, a promising anti-obesity target. It features a sulfonamide metal-binding group caged with a photoremovable coumarin and guided to mitochondria via a pyridinium moiety. Light exposure removes the cage, enabling precise spatial and temporal inhibition of mitochondrial CA-V activity.

Graphical abstract: A subcellularly targeted photocaged inhibitor for mitochondrial carbonic anhydrase V

Supplementary files

Article information

Article type
Communication
Submitted
16 May 2025
Accepted
30 Jun 2025
First published
04 Jul 2025
This article is Open Access
Creative Commons BY license

Dalton Trans., 2025,54, 10862-10867

A subcellularly targeted photocaged inhibitor for mitochondrial carbonic anhydrase V

N. N. Mafy, K. Aggarwal, S. Price, D. B. Hudson, E. Ye, D. Kolli and E. L. Que, Dalton Trans., 2025, 54, 10862 DOI: 10.1039/D5DT01161B

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements