A subcellularly targeted photocaged inhibitor for mitochondrial carbonic anhydrase V†
Noushaba Nusrat
Mafy, 
‡a
Kanchan
Aggarwal,
‡a
Sky
Price,
a
Dorothea B.
Hudson,
a
Elva
Ye,
a
Divya
Kolli
a
and
Emily L.
Que
*a
‡a
Kanchan
Aggarwal,
‡a
Sky
Price,
a
Dorothea B.
Hudson,
a
Elva
Ye,
a
Divya
Kolli
a
and
Emily L.
Que
*a
Abstract
We report the first photoactivatable inhibitor specifically targeting mitochondrial CA-V, a promising anti-obesity target. It features a sulfonamide metal-binding group caged with a photoremovable coumarin and guided to mitochondria via a pyridinium moiety. Light exposure removes the cage, enabling precise spatial and temporal inhibition of mitochondrial CA-V activity.
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