Issue 22, 2025
From the journal:

Dalton Transactions

Catalytic regioselective 3,4-difunctionalization of 3-iodo-o-carborane via Pd migration†

Xianren Jiang,ab   Chang-Hua Ding, ORCID logo a   Zaozao Qiu ORCID logo *ab  and  Zuowei Xie ORCID logo bc  

* Corresponding authors

a Innovation Institute of Carbon Neutrality, International Joint Laboratory of Catalytic Chemistry, Department of Chemistry, College of Sciences, Shanghai University, Shanghai 200444, China

b Shanghai-Hong Kong Joint Laboratory in Chemical Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200032, China
E-mail: qiuzz@sioc.ac.cn

c Shenzhen Grubbs Institute and Department of Chemistry, Southern University of Science and Technology, Shenzhen, Guangdong 518055, China

Abstract

A Pd-catalyzed one-pot regioselective difunctionalization of 3-iodo-o-carborane has been achieved for the synthesis of a wide variety of 3-alkyl-4-Nu-o-carboranes (Nu = aryl, alkyl, amino, or thio groups) in moderate to excellent yields. This protocol combines the sequential activation of cage B(3)–I and B(4)–H bonds via Pd 1,4-migration.

Graphical abstract: Catalytic regioselective 3,4-difunctionalization of 3-iodo-o-carborane via Pd migration

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Article information

DOI
https://doi.org/10.1039/D5DT00981B
Article type
Communication
Submitted
25 Apr 2025
Accepted
07 May 2025
First published
07 May 2025

Dalton Trans., 2025,54, 8764-8768

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Catalytic regioselective 3,4-difunctionalization of 3-iodo-o-carborane via Pd migration

X. Jiang, C. Ding, Z. Qiu and Z. Xie, Dalton Trans., 2025, 54, 8764 DOI: 10.1039/D5DT00981B

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