Excavating the Synthesis of Ru(II)/Ir(III)/Re(I)/Rh(III) based complexes as anticancer metallopharmaceuticals: Significance, Challenges and future perspective

Abstract

Metal complexes exhibit significant potential in the field of anticancer metallotherapeutics due to their high selectivity toward cancer cells and their effectiveness in targeted drug delivery. This frontier article summarizes recent advances in the synthesis of mono-, bi-, and mixed-metallic Ru(II)/Ir(III)/Re(I)/Rh(III) complexes for anticancer applications. Additionally, various therapeutic approaches and their mechanisms of action in Ru(II)/Ir(III)/Re(I)/Rh(III)-based complexes have been explored. Here we provide the insights on the contributions of various research groups toward the development of transition metal complexes with promising therapeutic potential. Emphasis has also been given on the different challenges faced throughout the designing and application process and the future perspective of these metallopharmaceuticals.