Reaction of a non-heme iron-nitrosyl with dioxygen: decomposition of the ligand through NOD-like activity

Abstract

A high-spin iron(II) nitrosyl, [(TPz)Fe(NO)](ClO₄)₂, 2 (TPz = Tris(3,5-dimethylpyrazol-1-ylmethyl)amine) with an {Fe(NO)}⁷ configuration was synthesized and characterized structurally. The dioxygen reactivity of complex 2 in acetonitrile solution results in the oxidation of the ligand. Chemical evidence suggests the involvement of a peroxynitrite intermediate in this reaction. A trapping experiment shows the formation of NO₂ during the reaction which supports the proposition of the involvement of the peroxynitrite intermediate. This study gives an insight into an alternate possibility from the dioxygen reactivity of metal-nitrosyl leading to nitric oxide dioxygenase (NOD) activity.