A sodium ion-selective photosensitizer: dibrominated F-BODIPY as a fluorescence imaging and therapeutic agent

Thomas Schwarze; Mazen Al Akrami; Julian Heinrich; Vinja Hergl; Eric Sperlich; Alexandra Kelling; Tobias Sprenger; Nicolas Jahn; Tillmann Klamroth; Nora Kulak

doi:10.1039/D5CP03172A

A sodium ion-selective photosensitizer: dibrominated F-BODIPY as a fluorescence imaging and therapeutic agent

Thomas Schwarze,

*^a Mazen Al Akrami,^a Julian Heinrich,

^a Vinja Hergl,^a Eric Sperlich,

^a Alexandra Kelling,^a Tobias Sprenger,^ab Nicolas Jahn,

^a Tillmann Klamroth

^a and Nora Kulak

*^a

Author affiliations

* Corresponding authors

^a Institute of Chemistry, University of Potsdam, 14476 Potsdam, Germany
E-mail: schwarth@uni-potsdam.de, nora.kulak@uni-potsdam.de

^b Faculty of Medicine, Health and Medical University (HMU), 14471 Potsdam, Germany

Abstract

Herein, we report that the production of singlet oxygen (¹O₂) is exclusively regulated by sodium ions in aqueous solution by the use of a Na⁺-selective photosensitizer (PS), a 2,6-dibrominated F-BODIPY dye equipped with benzo-15-crown-5. The PS showed an enhanced fluorescence quantum yield (Φ_f) and an enhanced singlet oxygen quantum yield (Φ_Δ) in the presence of Na⁺. A detailed theoretical study uncovered the underlying photophysical pathways which are responsible for both functional characteristics of the PS, therapeutic and Na⁺ imaging properties.

Physical Chemistry Chemical Physics

A sodium ion-selective photosensitizer: dibrominated F-BODIPY as a fluorescence imaging and therapeutic agent

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A sodium ion-selective photosensitizer: dibrominated F-BODIPY as a fluorescence imaging and therapeutic agent

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