Solvent selection as a major determinant of chiral resolution outcomes: the BINOL–DACH case study

Abstract

In this work, we undertook an in-depth study of the combination of two chiral molecules: 1,1′-Bi-2-naphtol (BINOL) and trans-cyclohexane-1,2-diamine (DACH). While exploring various solvents for developing resolution processes, we revealed a multitude of solid phases. Here is analyzed the different crystalline forms obtained in the selected solvents, underscoring the critical importance of the solvent choice for the development of a chiral resolution process.