A self-assembled supramolecular capsule that cocrystallizes with 1,4-disubstituted benzene derivatives

Abstract

A hydrogen-bonded dimeric supramolecular capsule was designed, synthesized and thoroughly characterized. Structural analyses using X-ray diffraction and DOSY NMR spectroscopy revealed that the flexible capsule could exist both in the solid state and in solution. Besides solvent molecules, various 1,4-disubstituted benzene derivatives could also be encapsulated by the supramolecular capsule. This study highlights the adaptability of the supramolecular capsule in host–guest chemistry and potential applications in materials science.