Synthesis of 11C-epoxides, aziridines, and cyclopropanes from structurally modified 11C-sulfur ylides

Abstract

A method for the radiosynthesis of ¹¹C-epoxides, aziridines, and cyclopropanes is described. Through generating ¹¹C-methyl sulfonium salts and corresponding sulfur ylides, the formation of ¹¹C-epoxides is possible in moderate-to-high radiochemical conversions. This method is translated to other 3-membered cyclic species and drug-like scaffolds. Automated radiosynthesis with this method suggests viability for clinical PET radiochemistry.