N-Heterocyclic Carbene-Catalyzed Asymmetric Synthesis of Bis-Ferrocene Derivatives bearing Two Stereogenic Planes

Abstract

The synthesis of ferrocene derivatives with dual planar chirality remains a significant challenge in asymmetric catalysis. This study presents an enantio- and diastereoselective N-heterocyclic carbene-catalyzed strategy to construct such compounds via a double desymmetrization reaction. Synthetic applications highlighted the versatility of these planar-planar chiral products in asymmetric synthesis as catalysts.