Camellia-like SnSe2 nanostructures for highly sensitive electrochemical detection of uric acid in urine for handheld point-of-care diagnostics

Zhuang Sun; Kaiqiang Sun; Peizheng Shi; Ningbin Zhao; Quanwang Liu; Zhiqiang Liang; Yufei Fang; Houmeng Yang; Hsu-Sheng Tsai; Lidong Wu; Tao Cai; Yuezhong Wang; Nan Jiang; Chen Ye; Li Fu; Xiancheng Li; Cheng-Te Lin

doi:10.1039/D5CC05561J

Camellia-like SnSe₂ nanostructures for highly sensitive electrochemical detection of uric acid in urine for handheld point-of-care diagnostics

Zhuang Sun,^ab Kaiqiang Sun,^b Peizheng Shi,^b Ningbin Zhao,^b Quanwang Liu,^b Zhiqiang Liang,^e Yufei Fang,^f Houmeng Yang,^g Hsu-Sheng Tsai,

^h Lidong Wu,ⁱ Tao Cai,

^cd Yuezhong Wang,^cd Nan Jiang,^cd Chen Ye,^j Li Fu,

*^k Xiancheng Li*^a and Cheng-Te Lin

*^cd

Author affiliations

* Corresponding authors

^a Department of Urology, Second Affiliated Hospital of Dalian Medical University, Dalian116023, Liaoning, China
E-mail: lxc2620@163.com

^b Qianwan Institute of CNITECH, Ningbo, P. R. China

^c State Key Laboratory of Advanced Marine Materials, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo, P. R. China
E-mail: linzhengde@nimte.ac.cn

^d Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing, P. R. China

^e Faculty of Sports Science, Ningbo University, Ningbo 315211, China

^f Department of Rehabilitation Medicine, Ningbo No. 2 Hospital, Ningbo 315010, China

^g Department of Urology, Ningbo No. 2 Hospital, Zhejiang, China

^h School of Physics, Harbin Institute of Technology, Harbin, P. R. China

ⁱ Key Laboratory of Control of Quality and Safety for Aquatic Products, Chinese Academy of Fishery Sciences, Beijing, P. R. China

^j School of Materials and Environmental Engineering, Chizhou University, Chizhou, P. R. China

^k College of Materials and Environmental Engineering, Hangzhou Dianzi University, Hangzhou, P. R. China
E-mail: fuli@hdu.edu.cn

Abstract

In this study, we present a camellia-like SnSe₂ nanostructure fabricated through a straightforward solvothermal process and integrated with reduced graphene oxide (rGO) to enable highly sensitive and selective electrochemical uric acid (UA) detection in artificial urine. The SnSe₂/rGO electrode exhibits excellent electrocatalytic activity towards UA oxidation, enabling a wide linear detection range of 20 nM–200 μM and an ultra-low detection limit of 11.4 nM. To further advance the practical application of this technology in point-of-care testing, we have designed a user-friendly, smartphone-integrated portable analytical device featuring Bluetooth connectivity, capable of providing real-time monitoring of UA levels in urine specimens.

Chemical Communications

Camellia-like SnSe₂ nanostructures for highly sensitive electrochemical detection of uric acid in urine for handheld point-of-care diagnostics

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Camellia-like SnSe₂ nanostructures for highly sensitive electrochemical detection of uric acid in urine for handheld point-of-care diagnostics

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