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Chemical Communications

The synthesis of [18F]SynVesT-1 and [18F]SynVesT-2 from enantioenriched boronic esters

Marong Qin,   Pawan Mishra,   Jasmine Hind,   Ian Fallis  and  Matthew Tredwell  

Abstract

Enantioenrcihed [18F]SynVesT-1 and [18F]SynVesT-2 are prepared from the corresponding enantioenriched arylboronic esters and [18F]fluoride mediated by (Py)4Cu(OTf)2. The 18F-reaction is optimised on an automated synthesiser to produce multi-GBq quantites of both radiotracers to support (pre)clinical imaging.

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DOI
https://doi.org/10.1039/D5CC05507E
Article type
Communication
Submitted
24 Sep 2025
Accepted
08 Oct 2025
First published
10 Oct 2025
This article is Open Access
Creative Commons BY license

Chem. Commun., 2025, Accepted Manuscript

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The synthesis of [18F]SynVesT-1 and [18F]SynVesT-2 from enantioenriched boronic esters

M. Qin, P. Mishra, J. Hind, I. Fallis and M. Tredwell, Chem. Commun., 2025, Accepted Manuscript , DOI: 10.1039/D5CC05507E

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