A chiroptical switcher: helical inversion of twisted porphyrin macrocycle synergistically controlled by combined stimuli of solvent and pressure

Abstract

Herein, we report the unprecedented discovery of 1 that possesses dynamically tunable chiroptical properties under hydrostatic pressure. Upon hydrostatic pressurization, the g factor inverts from negative to positive. These chiroptical switches are based on pressure-induced conformational change governed by the interplay between macrocyclic flexibility and solvent polarity.