Palladium-catalysed asymmetric allylic alkylation of hydantoins using bench-stable chiral palladium precatalysts

Abstract

Hydantoins are important heterocyclic scaffolds present in a number of pharmaceutically relevant compounds. We report here a practical, scalable and enantioselective Pd-catalyzed asymmetric allylic alkylation (Pd-AAA) approach to diversely substituted enantioenriched hydantoins. The method relies on the use of chiral bench-stable Pd-precatalysts previously developed by our groups. The synthetic utility of the method was further outlined by various successful post-modifications.