Issue 90, 2025
From the journal:

Chemical Communications

A glutathione-activated programmable DNA device for visual microRNA-210-enhanced photodynamic therapy of hypoxic lung cancer

Xiangdan Meng, ORCID logo †a   Sirong Sun,†b   Xueji Zhang ORCID logo c  and  Haifeng Dong ORCID logo *c  

* Corresponding authors

a Beijing Key Laboratory for Bioengineering and Sensing Technology, Research Centre for Bioengineering and Sensing Technology, School of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing 100083, China

b School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing 100083, P. R. China

c Marshall Laboratory of Biomedical Engineering School of Biomedical Engineering Health Science Centre, Shenzhen University, Shenzhen 518071, China
E-mail: hfdong@szu.edu.cn

Abstract

In this study, we construct a glutathione (GSH)-activated DNA nanodevice conjugated to a porphyrin-based metal–organic framework (PCN-224), creating an integrated theranostic platform for modulating hypoxia, enabling miRNA-210-specific imaging and enhancing photodynamic therapy (PDT).

Graphical abstract: A glutathione-activated programmable DNA device for visual microRNA-210-enhanced photodynamic therapy of hypoxic lung cancer

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Article information

DOI
https://doi.org/10.1039/D5CC05182G
Article type
Communication
Submitted
09 Sep 2025
Accepted
29 Sep 2025
First published
15 Oct 2025

Chem. Commun., 2025,61, 17681-17684

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A glutathione-activated programmable DNA device for visual microRNA-210-enhanced photodynamic therapy of hypoxic lung cancer

X. Meng, S. Sun, X. Zhang and H. Dong, Chem. Commun., 2025, 61, 17681 DOI: 10.1039/D5CC05182G

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