G-quadruplex DNA/iron cationic porphyrin catalyzes enantioselective carbon–silicon bond formation

Abstract

Enantioselective carbon−silicon bond formation is achieved by using a DNA-based biocatalyst via self-assembly of a G-quadruplex DNA (2KYO) and iron cationic porphyrin (FeTMPyP4). Remarkably, single-site or multiple-site combined base mutations on the 2KYO sequence enable enantioselectivity modulation from 86% to −78% ee, delivering a neural network-like DNA catalyst development paradigm for stereocontrolled bioconversion.