Direct utilization of hydrogen sulfide gas for aryl thiol synthesis via adaptive dynamic homogeneous catalysis in a flow system

Abstract

We present our initial results on C(sp²)–S cross-couplings employing the adaptive dynamic homogeneous catalysis (AD-HoC) strategy in combination with H₂S gas as an economically viable reagent for aryl thiol synthesis. To ensure the safe and efficient use of toxic H₂S gas, process development was carried out in a commercially available continuous flow photoreactor under visible-light irradiation, with a simple Brønsted acid playing a key role in promoting the reaction.