From the journal:

Chemical Communications

A snapshot of flavin-conjugated Pt anticancer agents: Pt(iv)-to-Pt(ii) reduction revealed by X-ray fluorescence imaging and XANES

Esteban Zingales, ORCID logo abc   Juan Sanchez-Camacho, ORCID logo ab   Jessica Walker, ORCID logo d   Luca Salassa ORCID logo abe  and  Carlos Sanchez-Cano ORCID logo *abe  

* Corresponding authors

a Donostia International Physics Center, Paseo Manuel de Lardizabal 4, Donostia-San Sebastian 20018, Spain
E-mail: carlos.sanchez@dipc.org

b Polimero eta Material Aurreratuak, Fisika, Kimika eta Teknologia, Kimika Fakultatea, Euskal Herriko Unibertsitatea UPV/EHU, 20018 Donostia-San Sebastian, Spain

c Center for Cooperative Research in Biomaterials (CIC biomaGUNE) Basque Research and Technology Alliance (BRTA), Paseo de Miramón 194, Donostia-San Sebastián 20014, Spain

d Diamond Light Source, Harwell Science and Innovation Campus, Didcot OX11 0DE, UK

e Ikerbasque, Basque Foundation for Science, Plaza de Euskadi 5, Bilbao 48009, Spain

Abstract

Synchrotron-based X-ray spectromicroscopy reveals enhanced cellular uptake and remarkably fast, efficient photoactivation of Pt(IV) prodrugs bearing flavin groups. These features correlate with superior anticancer activity compared to non-conjugated analogues, highlighting the potential of flavin-functionalised Pt(IV) complexes as candidates for photoactivated chemotherapy (PACT).

Graphical abstract: A snapshot of flavin-conjugated Pt anticancer agents: Pt(iv)-to-Pt(ii) reduction revealed by X-ray fluorescence imaging and XANES

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Article information

DOI
https://doi.org/10.1039/D5CC04792G
Article type
Communication
Submitted
19 Aug 2025
Accepted
14 Oct 2025
First published
14 Oct 2025

Chem. Commun., 2025, Advance Article

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A snapshot of flavin-conjugated Pt anticancer agents: Pt(IV)-to-Pt(II) reduction revealed by X-ray fluorescence imaging and XANES

E. Zingales, J. Sanchez-Camacho, J. Walker, L. Salassa and C. Sanchez-Cano, Chem. Commun., 2025, Advance Article , DOI: 10.1039/D5CC04792G

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