Photoinduced EDA complex triggered difluoroalkylation of quinoxalin-2(1H)-ones with unactivated alkenes and fluoroalkyl bromides

Abstract

A metal-free photo-induced three-component difluoroalkylation reaction between quinoxalin-2(1H)-ones, unactivated alkenes and fluoroalkyl bromides via an EDA strategy has been reported. This reaction was initiated by the photochemistry of electron donor acceptor (EDA) complexes formed by TMEDA and fluoroalkyl bromide. A variety of 3-difluoroalkylated quinoxalin-2(1H)-ones with diverse functional groups could be accessed under mild conditions.