Red/NIR-Emissive AIE Nanoprobe to Track Subcellular Dynamics in Photodynamic Therapy Process

Abstract

Precise monitoring of cancer treatment at the subcellular level remains a critical challenge. Therefore, a lysosome-specific AIE nanoprobe integrating stimulated emission depletion (STED) imaging and photodynamic therapy is reported here. The probe enables real-time visualization of lysosomal dynamics and reactive oxygen species (ROS)-mediated apoptosis, offering a powerful platform for high-resolution imaging-guided cancer diagnosis and treatment.