Enantioselective C–H amination catalyzed by homoleptic iron salox complexes

Abstract

Iron complexes bearing chiral salicyloxazoline (Salox) ligands catalyze the enantioselective intramolecular C–H bond amination of alkyl azides, reaching 58–76% ee for benzylic C–H bonds. Further, for the first time aliphatic C–H bond amination is demonstrated (∼40% ee). This class of catalysts even activates primary aliphatic C–H bonds, albeit with moderate ee.