Methionine-facilitated chalcogenation of peptides through palladium-catalyzed β-C(sp3)–H activation

Abstract

We report a novel methodology for the site-selective chalcogenation of peptides via Pd-catalyzed β-C(sp³)–H activation. In this study, native methionine residues serve as an intrinsic directing group, while various diaryl disulfides/diselenides act as coupling partners, affording chalcogenated peptides in moderate to good isolated yields.