SCHEDULED MAINTENANCE:
The hydrogenation of nicotinamide analogs using a Pt/SiO2 catalyst, followed by hydride transfer to NAD+, results in the highly selective generation of 1,4-NADH. N-Methyl nicotinamide exhibits the highest reactivity, achieving 98% selectivity at 20 °C under 1 atm H2. This strategy provides a practical and sustainable pathway for 1,4-NADH regeneration.
M. Hirano, W. Onodera, M. Tamura and Y. Amao, Chem. Commun., 2025, Accepted Manuscript , DOI: 10.1039/D5CC04253D
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