From the journal:

Chemical Communications

Direct palladium-catalyzed C-H arylation of bioactive triazolyl-C-nucleosides on a key position of the heterocyclic base

Bartosz Godlewski,   Nina Bozinovic,   Quentin Joachim,   Olivier Monasson,   Nadège Lubin-Germain  and  Angélique Ferry  

Abstract

Regarding the potential of nucleosides in therapeutics especially as antiviral and anticancer drugs, the expansion of the chemical space of such molecules appears urgent. Herein, a direct palladium-catalyzed C-H arylation of the triazolyl pseudonucleobase of bioactive C-nucleosides is described on 14 examples bearing different aryl moities and decorations on the nucleoside core.

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Article information

DOI
https://doi.org/10.1039/D5CC04215A
Article type
Communication
Submitted
24 Jul 2025
Accepted
18 Sep 2025
First published
19 Sep 2025

Chem. Commun., 2025, Accepted Manuscript

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Direct palladium-catalyzed C-H arylation of bioactive triazolyl-C-nucleosides on a key position of the heterocyclic base

B. Godlewski, N. Bozinovic, Q. Joachim, O. Monasson, N. Lubin-Germain and A. Ferry, Chem. Commun., 2025, Accepted Manuscript , DOI: 10.1039/D5CC04215A

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