An Fe(II) complex detects hydrogen peroxide with 1H and 19F magnetic resonance imaging responses

Sana Karbalaei; Alicja Franke; Achim Zahl; P. Raj Pokkuluri; Ronald J. Beyers; Ivana Ivanović-Burmazović; Christian R. Goldsmith

doi:10.1039/D5CC04066C

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

An Fe(ii) complex detects hydrogen peroxide with ¹H and ¹⁹F magnetic resonance imaging responses

Sana Karbalaei,^ab Alicja Franke,^c Achim Zahl,^d P. Raj Pokkuluri,^a Ronald J. Beyers,^e Ivana Ivanović-Burmazović^c and Christian R. Goldsmith

*^a

Author affiliations

* Corresponding authors

^a Department of Chemistry and Biochemistry, Auburn University, Auburn, AL 36849, USA
E-mail: crgoldsmith@auburn.edu

^b Department of Chemistry, Tuskegee University, Tuskegee, AL 36088, USA

^c Department of Chemistry, Ludwig-Maximilians-Universität München Butenandtstr. 5-13, Haus D 81377 München, Germany

^d Department of Chemistry and Pharmacy, Friedrich-Alexander-Universität (FAU), Erlangen-Nürnberg, 91058 Erlangen, Germany

^e Auburn University Magnetic Resonance Imaging Research Center, Auburn, AL 36849, USA

Abstract

We report the fluorinated quinol-containing ligand, 1,8-bis(2,5-dihydroxy-4-fluorobenzyl)-1,4,8,11-tetraazacyclotetradecane (F₂H₄qp4), and its highly water- and air-stable Fe(II) complex. Upon oxidation by H₂O₂, the ¹⁹F MRI signal of the complex decays while its ¹H MRI contrast increases; these spectroscopic responses enable the complex to ratiometrically detect H₂O₂.

Download options Please wait...

Supplementary files

Article information

DOI: https://doi.org/10.1039/D5CC04066C
Article type: Communication
Submitted: 18 Jul 2025
Accepted: 08 Sep 2025
First published: 16 Sep 2025

Download Citation

Chem. Commun., 2025,61, 15898-15901

Permissions

Request permissions

An Fe(II) complex detects hydrogen peroxide with ¹H and ¹⁹F magnetic resonance imaging responses

S. Karbalaei, A. Franke, A. Zahl, P. R. Pokkuluri, R. J. Beyers, I. Ivanović-Burmazović and C. R. Goldsmith, Chem. Commun., 2025, 61, 15898 DOI: 10.1039/D5CC04066C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Social activity

Fetching data from CrossRef.
This may take some time to load.

Chemical Communications