Accessing [6,6,5,6] tetracyclic indeno-quinolines via photomediated cascade reaction of electron-rich 1,7-enynes

Abstract

Synthesisof various sulfonyl and trifluoromethyl decorated tetracyclic indeno-quinolines from 1,7-enynes via a cascade radical addition-cyclization-aromatization sequence is presented. The reaction shows broad substrate scope with good functional group tolerance on the sulfonyl and o-alkynyl aniline derivatives. The protocol was successfully extended for late-stage modification of various sulfonyl-containing drugs and other radical precursors to obtain the corresponding indeno-quinolines in good yields. Control experiments corroborate the proposed photomediated radical cascade mechanism.

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Article information

Article type
Communication
Submitted
16 Jul 2025
Accepted
29 Aug 2025
First published
08 Sep 2025
This article is Open Access
Creative Commons BY license

Chem. Commun., 2025, Accepted Manuscript

Accessing [6,6,5,6] tetracyclic indeno-quinolines via photomediated cascade reaction of electron-rich 1,7-enynes

P. Yadav, A. A. Varma and P. Gopinath, Chem. Commun., 2025, Accepted Manuscript , DOI: 10.1039/D5CC04023J

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