From the journal:

Chemical Communications

Beyond serendipity: uncovering novel ratiometric urea·24DHBA cocrystals through mechanochemistry and MicroED

Ankur Bonia,a   Diptajyoti Gogoi,a   Nabadeep Kalita,a   Takanori Nakane, ORCID logo bc   Akihiro Kawamoto, ORCID logo bc   Khaled Althubeiti, ORCID logo d   Toshiyuki Sasaki, ORCID logo *e   Genji Kurisu ORCID logo *bcf  and  Ranjit Thakuria ORCID logo *ag  

* Corresponding authors

a Department of Chemistry, Gauhati University, Guwahati 781014, India
E-mail: ranjit.thakuria@gauhati.ac.in, ranjit.thakuria@gmail.com

b Institute for Protein Research, Osaka University, 3-2 Yamadaoka, Suita, Osaka 565-0871, Japan
E-mail: gkurisu@protein.osaka-u.ac.jp

c JEOL YOKOGUSHI Research Alliance Laboratories, Graduate School of Frontier Biosciences, Osaka University, 1-3 Yamadaoka, Suita, Osaka 565-0871, Japan
E-mail: gkurisu@protein.osaka-u.ac.jp

d Department of Chemistry, College of Science, Taif University, Taif 21944, Saudi Arabia

e Japan Synchrotron Radiation Research Institute (JASRI), 1-1-1 Kouto, Sayo-cho, Sayo-gun, Hyogo 679-5198, Japan
E-mail: toshiyuki.sasaki@spring8.or.jp

f Institute for Open and Transdisciplinary Research Initiatives, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan

g Faculty of Chemistry, University of Warsaw, 1 Pasteura Street, 02-093 Warsaw, Poland

Abstract

Mechanochemical synthesis of urea cocrystals with 2,4-dihydroxybenzoic acid (24DHBA) reveals two new stoichiometric forms: (urea)2·(24DHBA) and (urea)2·(24DHBA)2, not accessible via solution methods. The known (urea)0.5·(24DHBA) form remains the most stable. These findings provide critical insights into stoichiometric tuning of agro-cocrystals and pave the way for their practical application in sustainable agriculture.

Graphical abstract: Beyond serendipity: uncovering novel ratiometric urea·24DHBA cocrystals through mechanochemistry and MicroED

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Article information

DOI
https://doi.org/10.1039/D5CC03628C
Article type
Communication
Submitted
27 Jun 2025
Accepted
26 Aug 2025
First published
03 Sep 2025

Chem. Commun., 2025, Advance Article

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Beyond serendipity: uncovering novel ratiometric urea·24DHBA cocrystals through mechanochemistry and MicroED

A. Bonia, D. Gogoi, N. Kalita, T. Nakane, A. Kawamoto, K. Althubeiti, T. Sasaki, G. Kurisu and R. Thakuria, Chem. Commun., 2025, Advance Article , DOI: 10.1039/D5CC03628C

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