Photo/electro-catalytic stereo/enantioselective cross aza-pinacol coupling: synthesis of chiral amino alcohols

Abstract

The C–C cross-coupling reactions of amines/imines with carbonyls through aza–pinacol coupling have been used as methods for synthesizing pharmaceutically significant vicinal amino alcohols. Apart from traditional transition-metal catalysis, recent progress includes the use of photocatalysis and electrocatalysis as viable approaches. Further advances could be achieved by developing enantioselective methods to synthesize enantiomerically enriched amino alcohols. This review addresses these developments over the past decade.