Solid-state nanopore detection of metal ions via a DNAzyme–Catalytic Hairpin Assembly reaction

Abstract

Based on the indirect transduction strategy (ITS), we utilize a DNAzyme–CHA reaction to transduce lead(II), which cannot be directly detected by a glass nanopore, into controllable CHA products. This enables the accurate recognition of lead(II). The signal amplification method significantly enhances the resolution of glass nanopores and is expected to broaden their application scope.

Graphical abstract: Solid-state nanopore detection of metal ions via a DNAzyme–Catalytic Hairpin Assembly reaction

Supplementary files

Article information

Article type
Communication
Submitted
17 Jun 2025
Accepted
26 Jun 2025
First published
01 Jul 2025

Chem. Commun., 2025, Advance Article

Solid-state nanopore detection of metal ions via a DNAzyme–Catalytic Hairpin Assembly reaction

Y. Wang, L. Shao, C. Yu, Y. Li, R. Wu, J. Yu, L. Zhou, T. Wang, Y. Zhao, J. Zhu and B. Li, Chem. Commun., 2025, Advance Article , DOI: 10.1039/D5CC03429A

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