Chemoselective transfer hydrogenation and transfer deuteration of substituted quinolines using Hantzsch ester and D2O

Abstract

A novel strategy for the chemoselective transfer hydrogenation of complex quinolines using Hantzsch ester as a H-donor under ambient conditions is introduced. This approach provides a wide range of commercially important 1,2,3,4-tetrahydroquinolines in high yields up to 96%. Additionally, the deuteration of the quinoline ring positioned in densely functionalized multi-ring systems is also reported.