From the journal:

Chemical Communications

A TLR7/8 agonist–chitosan conjugate as an adjuvant for carbohydrate-based anticancer vaccine development

Xu-Guang Yin,†a   Guo-Zuo Tong,†a   Si-Qi Huang,a   li-Yuan Chen,a   Ang-Tao Yang,a   Wen-Jing Teng,a   Xiang Luoab  and  Ke-Wu Zhu ORCID logo *a  

* Corresponding authors

a Center for Drug Delivery System Research, School of Medicine, Shaoxing University, 900 Chengnan Avenue, Shaoxing, Zhejiang 312000, China
E-mail: kewuzhu@usx.edu.cn

b Zhejiang Engineering Research Center of Fat-soluble Vitamin, School of Chemistry and Chemical Engineering, Shaoxing University, 900 Chengnan Avenue, Shaoxing, Zhejiang 312000, China

Abstract

The TLR7/8 agonist imidazoquinoline (IMDQ), 1-(4-(amino-methyl)benzyl)-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-4-amine, conjugated to chitosan was found to be a superior adjuvant to aluminum salts for vaccination against tumor-associated carbohydrate antigens.

Graphical abstract: A TLR7/8 agonist–chitosan conjugate as an adjuvant for carbohydrate-based anticancer vaccine development

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Article information

DOI
https://doi.org/10.1039/D5CC03299G
Article type
Communication
Submitted
11 Jun 2025
Accepted
15 Aug 2025
First published
20 Aug 2025

Chem. Commun., 2025, Advance Article

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A TLR7/8 agonist–chitosan conjugate as an adjuvant for carbohydrate-based anticancer vaccine development

X. Yin, G. Tong, S. Huang, L. Chen, A. Yang, W. Teng, X. Luo and K. Zhu, Chem. Commun., 2025, Advance Article , DOI: 10.1039/D5CC03299G

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