Cobalt(iii)-catalyzed C–H functionalization of 2-arylthiazoles with maleimides or allyl acetate

Abstract

We report a cobalt-catalyzed C–H functionalization strategy for the modular alkylation and allylation of 2-arylthiazoles using maleimides or allyl acetates as coupling partners. This protocol enables efficient, ortho-selective C–H bond transformations in a single step, providing a broad range of functionalized thiazole derivatives. The developed methodology offers a novel and versatile platform for the direct C–H alkylation and allylation of 2-arylthiazole scaffolds, characterized by operational simplicity, a wide substrate scope, and high tolerance toward diverse functional groups.