Synthesis of Ferrocenyl/Phenyl Isothiazole-3-thione and Isoselenazole-3-selenone a New Heterocycle

Abstract

Direct one-pot synthesis for novel heterocycles isothiazole-3-thiones and isoselenazole-3-selenones via the annulation of ferrocenyl/ phenyl-β-chloro acrylaldehyde, amines and chalcogen powder (S and Se) has been established. The reaction was catalyzed by an environmentally benign iron cluster and Cu(OAc)2·H2O salt. The method is unique and rare as it consists the five consecutive bond formations. Herein, all the 1,2 N, S isothiozol-3-thiones and isoselenazole-3-selenones compounds are new and first time reported via this report.

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Article information

Article type
Communication
Submitted
11 Jun 2025
Accepted
21 Jul 2025
First published
21 Jul 2025

Chem. Commun., 2025, Accepted Manuscript

Synthesis of Ferrocenyl/Phenyl Isothiazole-3-thione and Isoselenazole-3-selenone a New Heterocycle

D. Sharma, V. TOMAR and R. K. Joshi, Chem. Commun., 2025, Accepted Manuscript , DOI: 10.1039/D5CC03270A

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