Synthesis of ferrocenyl/phenyl isothiazole-3-thione and isoselenazole-3-selenone as new heterocycles

Abstract

A direct one-pot synthesis for novel heterocycles, isothiazole-3-thiones and isoselenazole-3-selenones via the annulation of ferrocenyl/phenyl-β-chloro acrylaldehyde, amines and chalcogen powder (S and Se) has been established. The reaction was catalyzed by an environmentally benign iron cluster and Cu(OAc)2·H2O salt. The method is unique and rare as it consists of five consecutive bonds formation. Herein, all the 1,2 N, S isothiozole-3-thione and isoselenazole-3-selenone compounds are new and reported for the first time in this paper.

Graphical abstract: Synthesis of ferrocenyl/phenyl isothiazole-3-thione and isoselenazole-3-selenone as new heterocycles

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Article information

Article type
Communication
Submitted
11 Jun 2025
Accepted
21 Jul 2025
First published
21 Jul 2025

Chem. Commun., 2025, Advance Article

Synthesis of ferrocenyl/phenyl isothiazole-3-thione and isoselenazole-3-selenone as new heterocycles

D. Sharma, V. Tomar and R. K. Joshi, Chem. Commun., 2025, Advance Article , DOI: 10.1039/D5CC03270A

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